Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response
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چکیده
منابع مشابه
Cotranslational response to proteotoxic stress by elongation pausing of ribosomes.
Translational control permits cells to respond swiftly to a changing environment. Rapid attenuation of global protein synthesis under stress conditions has been largely ascribed to the inhibition of translation initiation. Here we report that intracellular proteotoxic stress reduces global protein synthesis by halting ribosomes on transcripts during elongation. Deep sequencing of ribosome-prote...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2016
ISSN: 0021-9258
DOI: 10.1074/jbc.m116.726398